Vulvovaginal Dermatology – Contact Dermatitis of the Vulva

Source: Vulvovaginal Dermatology – Dermatology Clinics
Contact Dermatitis of the Vulva

Figures

Two types: Irritant (ICD) and Allergic Contact Dermatitis (ACD)

Common vulvar irritants

Body Fluids
 Abnormal vaginal discharge
 Feces (enzymes)
 Semen
 Sweat
 Urine (ammonia)
Excessive bathing
Feminine hygiene products
 Depilatories
 Douches
 Feminine hygiene wipes
 Lubricants
 Panty liners
 Sanitary napkins/pads

Heat
 Heating pads
 Hair dryer
Medications
 Alcohol-based creams and gels
 Bichloroacetic acid, trichloroacetic acid
 Cantharidin
 Fluorouracil
 Imiquimod
 Phenol
 Podophyllin
 Propylene glycol
 Spermicides (foaming agents, emulsifiers)
Soaps and detergents (including bubble baths)


Common vulvar allergens

Anesthetics
 Amides (dibucaine, lidocaine)
 Crotamiton
 Diphenhydramine
 Esters (benzocaine, tetracaine)
Antibiotics
 Bacitracin
 Neomycin
 Polymyxin
 Sulfonamides
Antifungals
 Imidazoles (clotrimazole, miconazole)
 Nystatin
Antiseptics
 Chlorhexidine
 Gentian violet
 Mercuric chloride
 Phenylmercuric salts
 Povidone iodine
 Thimerosal
Corticosteroids
Douches
 Benzethonium chloride
 Fragrance/perfumes
 Methyl salicylate
 Oil of eucalyptus
 Oxyquinoline
 Phenylmercuric acetate
 Thymol

Emollients
 Glycerin
 Jojoba oil
 Lanolin
 Propylene glycol
Fragrance
 Balsam of Peru
 Cinnamic alcohol, cinnamic aldehyde
 Eugenol
 Isoeugenol
 Hydroxycitronellal
Nail Polish
 Toluene-sulfonamide formaldehyde resin
Nickel
Preservatives

 Bronopol
 Diazolidinyl urea
 Formaldehyde
 Imidazolidinyl urea
 Kathon
 Quaternium 15
Rubber
 Latex
 Mercaptobenzothiazole
 Thiurams
Sanitary Napkins
 Acetyl acetone
 Formaldehyde
 Fragrance
 Methacrylates
Spermicides
 Hexylresorcinol
 Nonoxynol
 Oxyquinoline sulfate
 Phenylmercuric acetate and butyrate
 Quinine hydrochloride


Clinical differential diagnosis of ICD and ACD

Acute vesiculoerosive contact dermatitis
 Bullous pemphigoid
 Candidiasis
 Erythema multiforme
 Fixed drug eruption
 Hailey-Hailey disease (benign familial pemphigus)
 Herpes simplex virus infection
 Lichen planus (erosive, bullous)
 Mucous membrane pemphigoid
 Pemphigus vulgaris

Chronic eczematous contact dermatitis
 Atopic dermatitis
 Candidiasis
 Erythrasma
 Extramammary Paget disease
 Lichen simplex chronicus
 Psoriasis
 Seborrheic dermatitis
 Squamous cell carcinoma in situ
 Tinea cruris

Prescription

Topical corticosteroid ointment:

  • hydrocortisone 2.5%, or
  • triamcinolone acetonide 0.1%, or
  • clobetasol propionate 0.05%, or
  • halobetasol 0.05%

Systemic corticosteroids:

  • Prednisone 40 –  60 mg daily in the morning (0.5 – 1.0mg/kg/d ideal body weight) with gradual tapering over 14 to 21 days
  • Triamcinolone acetonide IM 1 mg/kg as a single dose

Systemic prophylaxis for candidiasis

  • Fluconazole 150 mg PO weekly for all patients treated with topical or systemic corticosteroids

Treatment pruritus / scratching by combination of nonsedating and sedating antihistamines

  • In morning: Loratadine 10 mg or Fexofenadine 60 mg or Cetirizine 10 mg, 1-2 times/d
  • In evening: Hydroxyzine 25-100 mg, doxepin 10-75 mg

Treat secondary infection with systemic antibiotics, associated with prophylaxis for secondary vulvovaginal candidiasis using fluconazole 150 mg by mouth once weekly

Possible treatment of estrogen deficiency

Patient Education

  • To discontinue all potential irritants and allergens
  • To cleanse the vulva no more than twice daily using only lukewarm (not hot) water without soap, cleanser, or detergent
  • To do sitz baths 5 10 minutes, in which the patient fills the tub with only lukewarm water to cover the hips and buttocks for cleansing the vulva and for relief of pain or itching
  • To use a handheld shower spray can be used on a gentle setting for directed vulvar hygiene
  • To to use only hands to clean the vulva and to discontinue the use of all washcloths, loofahs and sponges
  • To pat the vulva dry, avoiding rubbing and additional friction
  • To apply plain white petrolatum should be applied as an emollient and barrier for fissured or eroded areas
  • To apply a copious layer of plain white petrolatum to all eroded areas before and after each bathroom use
  • To urinate while seated in a shallow tube of lukewarm water or by pouring lukewarm water over the vulva during micturition for reducing dysuria
  • To apply dilute aluminum acetate solutions for short periods as compresses to facilitate desiccation.
  • To apply the prescribed topical corticosteroid ointment initially twice daily until lesions have healed completely
  • To take medications as prescribed
  • To avoid topic antipuritics (diphenhydramine, lidocaine)
  • To avoid heat application
  • To apply cool compresses, cool gel packs, or frozen vegetables wrapped in thin fabric