Source: Vulvovaginal Dermatology – Dermatology Clinics
Contact Dermatitis of the Vulva
Two types: Irritant (ICD) and Allergic Contact Dermatitis (ACD)
Common vulvar irritants
Body Fluids
Abnormal vaginal discharge
Feces (enzymes)
Semen
Sweat
Urine (ammonia)
Excessive bathing
Feminine hygiene products
Depilatories
Douches
Feminine hygiene wipes
Lubricants
Panty liners
Sanitary napkins/pads
Heat
Heating pads
Hair dryer
Medications
Alcohol-based creams and gels
Bichloroacetic acid, trichloroacetic acid
Cantharidin
Fluorouracil
Imiquimod
Phenol
Podophyllin
Propylene glycol
Spermicides (foaming agents, emulsifiers)
Soaps and detergents (including bubble baths)
Common vulvar allergens
Anesthetics
Amides (dibucaine, lidocaine)
Crotamiton
Diphenhydramine
Esters (benzocaine, tetracaine)
Antibiotics
Bacitracin
Neomycin
Polymyxin
Sulfonamides
Antifungals
Imidazoles (clotrimazole, miconazole)
Nystatin
Antiseptics
Chlorhexidine
Gentian violet
Mercuric chloride
Phenylmercuric salts
Povidone iodine
Thimerosal
Corticosteroids
Douches
Benzethonium chloride
Fragrance/perfumes
Methyl salicylate
Oil of eucalyptus
Oxyquinoline
Phenylmercuric acetate
Thymol
Emollients
Glycerin
Jojoba oil
Lanolin
Propylene glycol
Fragrance
Balsam of Peru
Cinnamic alcohol, cinnamic aldehyde
Eugenol
Isoeugenol
Hydroxycitronellal
Nail Polish
Toluene-sulfonamide formaldehyde resin
Nickel
Preservatives
Bronopol
Diazolidinyl urea
Formaldehyde
Imidazolidinyl urea
Kathon
Quaternium 15
Rubber
Latex
Mercaptobenzothiazole
Thiurams
Sanitary Napkins
Acetyl acetone
Formaldehyde
Fragrance
Methacrylates
Spermicides
Hexylresorcinol
Nonoxynol
Oxyquinoline sulfate
Phenylmercuric acetate and butyrate
Quinine hydrochloride
Clinical differential diagnosis of ICD and ACD
Acute vesiculoerosive contact dermatitis
Bullous pemphigoid
Candidiasis
Erythema multiforme
Fixed drug eruption
Hailey-Hailey disease (benign familial pemphigus)
Herpes simplex virus infection
Lichen planus (erosive, bullous)
Mucous membrane pemphigoid
Pemphigus vulgaris
Chronic eczematous contact dermatitis
Atopic dermatitis
Candidiasis
Erythrasma
Extramammary Paget disease
Lichen simplex chronicus
Psoriasis
Seborrheic dermatitis
Squamous cell carcinoma in situ
Tinea cruris
Prescription
Topical corticosteroid ointment:
- hydrocortisone 2.5%, or
- triamcinolone acetonide 0.1%, or
- clobetasol propionate 0.05%, or
- halobetasol 0.05%
Systemic corticosteroids:
- Prednisone 40 – 60 mg daily in the morning (0.5 – 1.0mg/kg/d ideal body weight) with gradual tapering over 14 to 21 days
- Triamcinolone acetonide IM 1 mg/kg as a single dose
Systemic prophylaxis for candidiasis
- Fluconazole 150 mg PO weekly for all patients treated with topical or systemic corticosteroids
Treatment pruritus / scratching by combination of nonsedating and sedating antihistamines
- In morning: Loratadine 10 mg or Fexofenadine 60 mg or Cetirizine 10 mg, 1-2 times/d
- In evening: Hydroxyzine 25-100 mg, doxepin 10-75 mg
Treat secondary infection with systemic antibiotics, associated with prophylaxis for secondary vulvovaginal candidiasis using fluconazole 150 mg by mouth once weekly
Possible treatment of estrogen deficiency
Patient Education
- To discontinue all potential irritants and allergens
- To cleanse the vulva no more than twice daily using only lukewarm (not hot) water without soap, cleanser, or detergent
- To do sitz baths 5 10 minutes, in which the patient fills the tub with only lukewarm water to cover the hips and buttocks for cleansing the vulva and for relief of pain or itching
- To use a handheld shower spray can be used on a gentle setting for directed vulvar hygiene
- To to use only hands to clean the vulva and to discontinue the use of all washcloths, loofahs and sponges
- To pat the vulva dry, avoiding rubbing and additional friction
- To apply plain white petrolatum should be applied as an emollient and barrier for fissured or eroded areas
- To apply a copious layer of plain white petrolatum to all eroded areas before and after each bathroom use
- To urinate while seated in a shallow tube of lukewarm water or by pouring lukewarm water over the vulva during micturition for reducing dysuria
- To apply dilute aluminum acetate solutions for short periods as compresses to facilitate desiccation.
- To apply the prescribed topical corticosteroid ointment initially twice daily until lesions have healed completely
- To take medications as prescribed
- To avoid topic antipuritics (diphenhydramine, lidocaine)
- To avoid heat application
- To apply cool compresses, cool gel packs, or frozen vegetables wrapped in thin fabric