Selective Serotonin Reuptake Inhibitors (SSRI) & Non-SSRIs

Feb 23, 2020 admin DƯỢC KHOA 0

Classes of Selective Serotonin Reuptake Inhibitors (SSRI)

  1. Monocyclic: Fluvoxamine (Luvox)
  2. Bicyclic: Fluoxetine HCl (Prozac)
  3. Tricyclic: Sertraline HCl (Zoloft)
  4. Tetracyclic: Paroxetine HCl (Paxil)

Indications of SSRIs

Indications: First Line

  1. Major Depression
  2. Generalized Anxiety Disorder
    Fluvoxamine (Luvox)
    Paroxetine (Paxil)
  3. Premature Ejaculation
    Paroxetine (Paxil)
    Sertraline (Zoloft)
    Fluoxetine (Prozac)

Indications: Adjunctive

  1. Migraine Headache Prophylaxis
    Fluoxetine (Prozac)
  2. Diabetic Neuropathy
    Paroxetine (Paxil)
  3. Fibromyalgia
    Fluoxetine (Prozac)
  4. Neurocardiogenic Syncope
    Paroxetine (Paxil)
    Sertraline (Zoloft)
    Fluoxetine (Prozac)

Other new Antidepressants (non-SSRI)

  1. Serotonin Modulator and Stimulator (same activity as SSRI)
    Vortioxetine (Brintellix)
    New in 2013, similar to generic SSRIs, with more Nausea at 10x the cost
  2. Serotonin Norepinephrine Reuptake Inhibitors (SNRI)
    Venlafaxine (Effexor)
    Same class as Tricyclic Antidepressants
  3. Norepinephrine Dopamine Reuptake Inhibitor (NDRI)
    Bupropion (Wellbutrin, Zyban)
  4. Serotonin Antagonist and Reuptake Inhibitor (SARI)
    Nefazodone (Serzone)
    Same class as Trazodone (Desyrel)
  5. Norepinephrine Antagonist Serotonin Antagonist (NASA)
    Mirtazapine (Remeron)

 

 

 

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