Medication Causes of Edema

Medication Causes of Edema

Aka: Medication Causes of Edema, Edema Secondary to Medications

II. Mechanism

  1. Edema is typically due to salt and water retention unless otherwise noted

IV. Causes: Endocrine agents

V. Causes: Neurologic and Psychiatric Medications

  1. Antidepressants
    1. Monoamine Oxidase Inhibitors
    2. Trazodone
  2. Antipsychotics: Phenothiazines
    1. Thioridazine (Mellaril)
    2. Chlorpromazine (Thorazine)
    3. Trifluoperazine (Stelazine)
    4. Thiothixene (Navane)
  3. Neurologic Medications
    1. Dopamine Agonists such as Pramipexole (Mirapex)
    2. Gabapentin
    3. Pregabalin

VI. Causes: Chemotherapy

  1. Interleukin-2 (Increased Vascular permeability)
  2. Interleukin-4
  3. Interferon alfa
  4. Docetaxel (Taxotere)
  5. Cyclophosphamide
  6. Cyclosporine
  7. Mithramycin
  8. Cytosine Arbinoside
  9. Granulocyte colony-stmulating factor
  10. GranulocyteMacrophage colony stimulating factor

VII. Causes: Miscellaneous agents

  1. Acyclovir (Zovirax)
  2. Buprenorphine
  3. Diuretic Abuse or Laxative abuse
    1. Increases renin and aldosterone levels
    2. Rebound salt retention on stopping medication
  4. Nonsteroidal Antiinflammatory Drugs (NSAIDs)
    1. Ibuprofen
    2. Celecoxib (Celebrex)

VIII. References

Images: Related links to external sites (from Bing)